| Pair Name | Honokiol, Celecoxib | ||
| Phytochemical Name | Honokiol (PubChem CID: 72303 ) | ||
| Anticancer drug Name | Celecoxib (PubChem CID: 2662 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Honokiol, Celecoxib | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | FOXM1 | hsa2305 |
| Down-regulation | Expression | FOXP3 | hsa50943 | |
| Down-regulation | Expression | ITGAM | hsa3684 | |
| Down-regulation | Expression | MKI67 | hsa4288 | |
| Down-regulation | Expression | NNT | hsa23530 | |
| Down-regulation | Expression | PECAM1 | hsa5175 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| In Vitro Model | 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 |
| Result | The combined treatment with PV-CXB and PV-HNK showed synergistic effect both in vitro and in vivo | |||
| No. | Title | Href |
|---|---|---|
| 1 | Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer. Eur J Pharm Sci. 2020 Apr 15;146:105277. doi: 10.1016/j.ejps.2020.105277. | Click |
